STEVEN J. STELMAN, PMP
San Diego, CA
619.501.0456


SUMMARY

A skilled manager and creative senior bioinformatics scientist with over 15 years of diversified research and development experience in both small company and global corporate environments. Continuous record of accomplishment with extensive experience in applied bioinformatics, including:
  • Proven skills in people and project management, scientific software development, user support and training, and interpretation of complex computational data, supported by molecular biology laboratory background.
  • Experience in corporate collaborations and development of expert in-house technologies from early design through product launch.
  • Ability to clearly communicate technical information across a broad range of disciplines and partners, including scientists, computer support staff, attorneys, and regulators.

PROFESSIONAL EXPERIENCE

Director of IT and Bioinformatics(2015 - present)
Active Motif, Carlsbad, CA

People & Project Management:

  • Planned and directed the design, development and management of information processing and electronic communication systems needed for the company’s general business activities.
  • Directed internal and external bioinformatics software development projects.
  • Developed and maintained commercial bioinformatics pipelines for Epigenetic Services Division (ChIP-Seq, RNA-Seq, and other NGS applications).
  • Managed all engineering, technical support, and manufacturing activities for TimeLogic Division.
Manager, TimeLogic Group(2008 - 2015)
Active Motif, Carlsbad, CA

People & Project Management:

  • Managed all engineering, technical support, and manufacturing activities for TimeLogic Division.
  • Developed and implemented project plans for internal bioinformatics software products and external corporate collaborations.
  • Managed the development, testing and commercial release of next-generation Field Programmable Gate Array (FPGA) accelerator cards.
  • Streamlined manufacturing and quality control testing processes to improve product reliability.
  • Developed technical product documentation and training materials.
Bioinformatics R&D Project Manager, TimeLogic Group(2006 - 2007)
Active Motif, Carlsbad, CA

Project Management:

  • Developed and implemented project plans for the development and commercial launch of graphical bioinformatics pipelining software product.
  • Managed in-house engineers and outsourced contract programmers in India to coordinate deliverables, assure quality control, and meet project timelines.
Instructor, Department of Bioscience, UCSD Extension(2004 - 2013)
University of California, San Diego, CA

Algorithm Development and Data Analysis:

  • Developed and taught Databases and Genome Analysis course, a required core curriculum for the UCSD Extension Certificate Programs in Bioinformatics/Life Sciences Information Technology. Focus on theory of algorithm development and implementation of high through-put data analysis.
Bioinformatics Specialist, Systems Biology Group, Biotechnology(2003 - 2006)
The Dow Chemical Company, San Diego, CA

Bioinformatics Programming:

  • Programmed an improved automated pipeline and developed visualization tools for annotation of genomes, enabling enhancement of mining and cloning strategies for novel product development.
  • Assembled and analyzed genome of Pseudomonas fluorescens, Dow's next generation Pfenex™ expression system for production of biotherapeutics.
  • Wrote code to perform quality controls on generated data and designed laboratory experiments to validate in-silico predictions.
Bioinformatics Research Biologist, Plant Genetics and Biotechnology(1999 - 2002)
Dow AgroSciences, San Diego, CA

Bioinformatics Development & Training:

  • Improved corporate research and discovery capabilities by implementing in-house bioinformatics tools, maintaining company-wide bioinformatics servers, and integrating and curating public and proprietary databases.
  • Wrote scripts to parse genomic and microarray data to enable high through-put analysis of several hundred thousand EST sequences.
  • Designed and taught bioinformatics training courses to over 100 Dow AgroSciences and Dow Chemical research staff at introductory and advanced levels, enabling broad and efficient application of computational resources toward discovery project goals.
Regulatory Bioinformatics:
  • Developed algorithms, databases, and methodology and authored regulatory studies to assess new biotech proteins as potential food allergens and toxins. Enabled successful registration of five transgenic or recombinant biotech products with U.S. Environmental Protection Agency, U.S. Food & Drug Agency, and foreign regulatory agencies.
  • Influenced development of international policy for registration of genetically modified products by co-authoring review of bioinformatics tools and databases for the study of protein allergens as an expert consultant to the European Commission Joint Research Centre.
Cross-Functional Project Management:
  • Evaluated new software and successfully negotiated numerous complex software contracts to save over $100,000 while increasing computational capabilities and integrating cross-functional and legacy data required for discovery, patent, and regulatory support.
  • Led project teams and facilitated exchanges between scientists and computer staff within Dow and with collaborators, including Dupont/Pioneer Hi-Bred.
Research Associate I & II, Bioinformatics and Molecular Biology
Research Assistant I & II, Bioinformatics and Molecular Biology		(1993 - 1999)
Mycogen Corporation, San Diego, CA

Bioinformatics Infrastructure:

  • Designed and implemented bioinformatics infrastructure to integrate automated DNA sequencing, public databases, analysis tools, and construct design across previously incompatible Windows NT, Macintosh, UNIX, and VMS platforms.
  • Developed and maintained company's first intranet to facilitate exchange and provide quality assurance of data generated by disparate research groups.
Intellectual Property Support:
  • Applied bioinformatics analysis for support of numerous corporate patent litigation efforts to protect company's intellectual property.
  • Constructed and curated proprietary gene and protein databases to enable protein family analysis and design of novel recombinants with improved activity.
Molecular & Computational Biology:
  • Designed and patented plant-optimized transgenes for expression of bacterial genes in corn, cotton, and sunflower, including the synthetic Cry1F insecticidal gene, active component of insect resistant Herculex I™ corn and WideStrike™ cotton, Dow AgroSciences' first two transgene products.
  • Cloned, expressed, and patented novel Bacillus thuringiensis cry1Be1 delta endotoxin gene (GenBank accession AF077326) for resistance management of insecticidal activity against European Corn Borer.
  • Sub-cloned plant transcription units for Agrobacterium mediated Ti-plasmid-based binary plant expression vector for transformation of insecticidal traits into crops.
Haygood Lab, Scripps Institute of Oceanography, La Jolla, CA(1991 - 1992)
  • Constructed fosmid library and subcloned luxB gene from unculturable bacterial symbiont of flashlight fish Kryptophanaron alfredi.

EDUCATION

B.S., Biochemistry and Cell Biology, University of California, San Diego.

Certificate in UNIX System Administration, UCSD Extension, San Diego, CA.

LEADERSHIP AND TRAINING

Project Management Professional (PMI PMP)

San Diego Bioinformatics Forum: Chair of Organizing Committee (www.sdbioinfo.org)

UCSD Extension: Life Sciences Information Technology Advisory Board

Interaction Associates: Facilitative Leadership.

The Ken Blanchard Company: Situational Leadership II.

Franklin/Covey: The Seven Habits of Highly Effective People.

AWARDS & ACTIVITIES

Dow AgroSciences Discovery Recognition Award: Excellence in Team Risk Taking.

Mycogen Corporation Vice President's Award: Discovery of Corn Rootworm Active Gene.

ISSUED U.S. PATENTS

U.S. Patent 10,023,921. July 17, 2018.
Barbour, Eric, James Wayne Bing, Guy A. Cardineau, Robert F. Cressman, Jr., Manju Gupta, Mary E. Hartnett Locke, David Hondred, Joseph W. Keaschall, Michael G. Koziel, Terry EuClaire Meyer, Daniel Moellenbeck, Kenneth Edwin Narva, Wilas Nirunsuksiri, Steven W. Ritchie, Marjorie L. Rudert, Craig D. Sanders, Aihua Shao, Steven Jeffrey Stelman, David S. Stucker, Laura Ann Tagliani, Willam M. Van Zante. Corn event TC1507 and methods for detection thereof.
U.S. Patent 8,901,378. December 2, 2014.
Barbour, Eric, James Wayne Bing, Guy A. Cardineau, Robert F. Cressman, Jr., Manju Gupta, Mary E. Hartnett Locke, David Hondred, Joseph W. Keaschall, Michael G. Koziel, Terry EuClaire Meyer, Daniel Moellenbeck, Kenneth Edwin Narva, Wilas Nirunsuksiri, Steven W. Ritchie, Marjorie L. Rudert, Craig D. Sanders, Aihua Shao, Steven Jeffrey Stelman, David S. Stucker, Laura Ann Tagliani, Willam M. Van Zante. Corn event TC1507 and methods for detection thereof.
U.S. Patent 7,989,607. August 2, 2011.
Barbour, Eric, James Wayne Bing, Guy A. Cardineau, Robert F. Cressman, Jr., Manju Gupta, Mary E. Hartnett Locke, David Hondred, Joseph W. Keaschall, Michael G. Koziel, Terry EuClaire Meyer, Daniel Moellenbeck, Kenneth Edwin Narva, Wilas Nirunsuksiri, Steven W. Ritchie, Marjorie L. Rudert, Craig D. Sanders, Aihua Shao, Steven Jeffrey Stelman, David S. Stucker, Laura Ann Tagliani, Willam M. Van Zante. Corn event TC1507 and methods for detection thereof.
U.S. Patent 7,514,544. April 7, 2009.
Barbour, Eric, James Wayne Bing, Guy A. Cardineau, Robert F. Cressman, Jr., Manju Gupta, Mary E. Hartnett Locke, David Hondred, Joseph W. Keaschall, Michael G. Koziel, Terry EuClaire Meyer, Daniel Moellenbeck, Kenneth Edwin Narva, Wilas Nirunsuksiri, Steven W. Ritchie, Marjorie L. Rudert, Craig D. Sanders, Aihua Shao, Steven Jeffrey Stelman, David S. Stucker, Laura Ann Tagliani, Willam M. Van Zante. Corn event TC1507 and methods for detection thereof.
U.S. Patent 7,449,564. November 11, 2008.
Barbour, Eric, James Wayne Bing, Guy A. Cardineau, Robert F. Cressman, Jr., Manju Gupta, Mary E. Hartnett Locke, David Hondred, Joseph W. Keaschall, Michael G. Koziel, Terry EuClaire Meyer, Daniel Moellenbeck, Kenneth Edwin Narva, Wilas Nirunsuksiri, Steven W. Ritchie, Marjorie L. Rudert, Craig D. Sanders, Aihua Shao, Steven Jeffrey Stelman, David S. Stucker, Laura Ann Tagliani, Willam M. Van Zante. Corn event TC1507 and methods for detection thereof.
U.S. Patent 7,435,807. October 14, 2008.
Barbour, Eric, James Wayne Bing, Guy A. Cardineau, Robert F. Cressman, Jr., Manju Gupta, Mary E. Hartnett Locke, David Hondred, Joseph W. Keaschall, Michael G. Koziel, Terry EuClaire Meyer, Daniel Moellenbeck, Kenneth Edwin Narva, Wilas Nirunsuksiri, Steven W. Ritchie, Marjorie L. Rudert, Craig D. Sanders, Aihua Shao, Steven Jeffrey Stelman, David S. Stucker, Laura Ann Tagliani, Willam M. Van Zante. Corn event TC1507 and methods for detection thereof.
U.S. Patent 7,417,132. August 26, 2008.
Barbour, Eric, James Wayne Bing, Guy A. Cardineau, Robert F. Cressman, Jr., Manju Gupta, Mary E. Hartnett Locke, David Hondred, Joseph W. Keaschall, Michael G. Koziel, Terry EuClaire Meyer, Daniel Moellenbeck, Kenneth Edwin Narva, Wilas Nirunsuksiri, Steven W. Ritchie, Marjorie L. Rudert, Craig D. Sanders, Aihua Shao, Steven Jeffrey Stelman, David S. Stucker, Laura Ann Tagliani, Willam M. Van Zante. Corn event TC1507 and methods for detection thereof.
U.S. Patent 7,288,643. October 30, 2007.
Barbour, Eric, James Wayne Bing, Guy A. Cardineau, Robert F. Cressman, Jr., Manju Gupta, Mary E. Hartnett Locke, David Hondred, Joseph W. Keaschall, Michael G. Koziel, Terry EuClaire Meyer, Daniel Moellenbeck, Kenneth Edwin Narva, Wilas Nirunsuksiri, Steven W. Ritchie, Marjorie L. Rudert, Craig D. Sanders, Aihua Shao, Steven Jeffrey Stelman, David S. Stucker, Laura Ann Tagliani, Willam M. Van Zante. Corn event TC1507 and methods for detection thereof.
U.S. Patent 6,673,990. January 6, 2004.
Cardineau, Guy A., Stelman, Steven J., Narva, Kenneth E. Plant-optimized genes encoding pesticidal Cry protein toxins.
U.S. Patent 6,340,593. January 22, 2002.
Cardineau, Guy A., Stelman, Steven J., Narva, Kenneth E. Plant-optimized polynucleotides encoding approximately 15 kDa and approximately 45 kDa pesticidal proteins.
U.S. Patent 6,218,188. April 17, 2001.
Cardineau, Guy A., Stelman, Steven J., Narva, Kenneth E. Plant-optimized genes encoding pesticidal toxins.
U.S. Patent 6,150,589. November 21, 2000.
Payne, Jewel, Cummings, David A., Cannon, Raymond J. C., Narva, Kenneth E., Stelman, Steve. Genes encoding lepidopteran-active toxins from Bacillus thuringiensis isolate PS158C2.
U.S. Patent 5,723,758. March 3, 1998.
Payne, Jewel, Cummings, David A., Cannon, Raymond J. C., Narva, Kenneth E., Stelman, Steve. Bacillus thuringiensis genes encoding lepidopteran-active toxins.
Other patents pending.

PUBLICATIONS

Jin, Hongfan; Retallack, Diane; Stelman, Steven; Hershberger, C; Ramseier, Tom. 2007. Characterization of the SOS response of Pseudomonas fluorescens strain DC206 using whole genome transcript analysis. FEMS Microbiology Letters. 269(2): 256-64. [DOI: 10.1111/j.1574-6968.2007.00630.x]

Brusic, Vladimir; Millot, Michel; Petrovsky, Nikolai; Gendel, Steven M.; Gigonzac, Olivier; Stelman, Steven J. 2003. Allergen Databases. Allergy. 58(11): 1093-1100. [DOI: 10.1034/j.1398-9995.2003.00248.x]

Brusic, Vladimir; Petrovsky, Nikolai; Gendel, Steven M.; Millot, Michel; Gigonzac, Olivier; Stelman, Steven J. 2003. Computational Tools for the Study of Allergens. Allergy. 58(11): 1083-1092. [DOI: 10.1034/j.1398-9995.2003.00224.x]

Landry, Timothy D.; Chew, Lawrence; Davis, John W.; Frawley, Nile; Foley, Holly H.; Stelman, Steven J.; Thomas, Johnson; Wolt, Jeffrey; Hanselman, David S. 2003. Safety evaluation of an a-amylase enzyme preparation derived from the archaeal order Thermococcales as expressed in Pseudomonas fluorescens biovar I. Regul. Toxicol. Pharmacol. 37(1): 149-168. [DOI: 10.1016/S0273-2300(03)00002-3]

Moellenbeck, Daniel J.; Peters, Melvin L.; Bing, James W.; Rouse, James R.; Higgins, Laura S.; Sims, Lynne; Nevshemall, Tony; Marshall, Lisa; Ellis, R. Tracy; Bystrak, Paul G.; Lang, Bruce A.; Stewart, James L.; Kouba, Kristen; Sondag, Valerie; Gustafson, Vicki; Nour, Katy; Xu, Deping; Swenson, Jan; Zhang, Jian; Czapla, Thomas; Schwab, George; Jayne, Susan; Stockhoff, Brian A.; Narva, Kenneth; Schnepf, H. Ernest; Stelman, Steven J.; Poutre, Candace; Koziel, Michael; Duck, Nicholas. 2001. Insecticidal Proteins from Bacillus thuringiensis Protect Corn from Corn Rootworms. Nat. Biotechnol. 19(7): 668-672. [DOI: 10.1038/90282]